A randomized, controlled trial comparing topical steroid application to wet versus dry skin in children with atopic dermatitis (AD). Vehicle effects in percutaneous absorption. Topical therapies for the treatment of plaque psoriasis. Samarasekera EJ, Sawyer L, Wonderling D, et al. Patients' vehicle preference for corticosteroid treatments of scalp psoriasis. Are ointments better than other vehicles for corticosteroid treatment of psoriasis?. Relative efficacy and interchangeability of various clobetasol propionate vehicles in the management of steroid-responsive dermatoses. The topical corticosteroid classification called into question: towards a new approach. A systematic review of topical corticosteroid withdrawal in patients with atopic dermatitis and other dermatoses. Tachyphylaxis to topical glucocorticoids?. Safety of topical corticosteroids in pregnancy. Update on the systemic risks of superpotent topical steroids. Adverse effects of topical glucocorticosteroids. Hengge UR, Ruzicka T, Schwartz RA, et al. Tadicherla S, Ross K, Shenefelt PD, et al. Guidelines of care for the use of topical glucocorticosteroids. Method for comparing percutaneous absorption of steroids. A double-blind controlled comparison of generic and trade-name topical steroids using the vasoconstriction assay. Critical factors determining the potency of topical corticosteroids. Kirkland R, Pearce DJ, Balkrishnan R, et al. Betamethasone cream for the treatment of pre-pubertal labial adhesions. Infantile acropustulosis revisited: history of scabies and response to topical corticosteroids. A comparative study of 20% azelaic acid cream monotherapy versus a sequential therapy in the treatment of melasma in dark-skinned patients. Topical dexamethasone for recurrent aphthous ulceration reduces pain and size and increases healing with no significant adverse events. An 18-month follow-up study after randomized treatment of phimosis in boys with topical steroid versus placebo. A comparison of oral and topical corticosteroids in patients with bullous pemphigoid. Vitiligo: a retrospective comparative analysis. Clobetasol propionate, 0.05%, vs hydrocortisone, 1%, for alopecia areata in children. Topical interventions for genital lichen sclerosus. Topical treatments for chronic plaque psoriasis. Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis. Siegfried EC, Jaworski JC, Kaiser JD, et al. Ointment, cream, lotion, gel, foam, solution, shampoo, spray There is no specified time limit for low-potency topical corticosteroid use.īetamethasone dipropionate augmented 0.05% Topical corticosteroids are applied once or twice per day for up to three weeks for super-high-potency corticosteroids or up to 12 weeks for high- or medium-potency corticosteroids. One fingertip unit is the amount of medication dispensed from the tip of the index finger to the crease of the distal interphalangeal joint and covers approximately 2% body surface area on an adult. Patients may be taught application using the fingertip unit method. Correct patient application is critical to successful use. The quantity of corticosteroid prescribed depends on the duration of treatment, the frequency of application, the skin location, and the total surface area treated. They are available in formulations such as ointments, creams, lotions, gels, foams, oils, solutions, and shampoos. Topical corticosteroids can work safely and effectively in patients who are pregnant or lactating. When prescribing topical corticosteroids for use in children, lower potencies and shorter durations should be used. The risk of adverse effects increases with prolonged use, a large area of application, higher potency, occlusion, and application to areas of thinner skin such as the face and genitals. Topical corticosteroids are classified by strength and the risk of adverse effects such as atrophy, striae, rosacea, telangiectasias, purpura, and other cutaneous and systemic reactions. Topical corticosteroids are an essential tool for treating inflammatory skin conditions such as psoriasis and atopic dermatitis.
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